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    北理工在《Accounts of chemical research》發表納米酶綜述文章

      納米酶是一類本身蘊含酶學特性的納米材料,具有催化活性強、穩定性好、成本低等優勢。自從2007年閻錫蘊院士團隊首次報道納米酶新概念以來(Nature Nanotechnology,2007),迄今,全球已有29個國家的290多個實驗室報道了320余種納米酶,逐漸形成了納米酶新型交叉學科領域。納米酶的出現是人工模擬酶研究領域的重大進展,它不僅揭示了惰性無機材料在納米尺度呈現出不可預見的酶學特性,還使模擬酶研究領域從有機化學拓展到無機納米材料領域。更重要的是,納米酶克服了天然酶脆弱和昂貴的弊端,突破了以往模擬酶催化效率不高的局限性,目前已被廣泛應用到疾病診斷和治療、傳染病防控、環境監測和污水處理等多個領域。納米酶是目前為數不多的由中國科學家發現、被國際同行認可,并迅速實現成果轉化的新型交叉學科領域。

      近日,北京理工大學材料學院梁敏敏教授與中科院生物物理所閻錫蘊院士在國際頂級期刊《Accounts of chemical research》(影響因子21.661)上對納米酶進行了全面綜述。文章概述了納米酶的發展歷程、性能優勢及現有的局限性,指出納米酶同時具有的酶催化特性及納米材料特有的光、電、磁等理化特性,使得納米酶特別適合作為多功能探針用于疾病的診斷與治療,另外文章還總結了納米酶作為天然酶的替代品在工業制造、污水處理、抗菌洗消及納米酶載藥等多個領域的應用,隨之文章提出如何將一批原創的納米酶新技術迅速轉化為新產品,如何制定行業標準,進行納米酶的理性設計,推動納米酶在臨床醫學、軍工、公共安全、環境治理等領域的快速應用,開啟納米酶應用新時代。最后,作者展望了納米酶學產生的客觀條件及未來對傳統酶學帶來的影響及機遇。

      論文發表在《Accounts of chemical research》上。相關研究工作獲得國家自然科學基金優秀青年科學基金項目、國家重點研發計劃-納米科技專項及中國科學院前沿重點項目等項目的資助。

      文章鏈接為:https://pubs.acs.org/doi/10.1021/acs.accounts.9b00140

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